The local CBS affiliate reported that eight people were confirmed dead, while Fox put the death toll at four.
A police spokesman addressing reporters at the scene confirmed multiple casualties and said, three officers, where shot before the shooter was taken into custody.
The condition of the officers was not immediately clear.
Police were still clearing the building, the official said.
Pittsburgh’s Public Safety department, which includes the police, earlier tweeted that an active shooter was in the area near the synagogue, urging residents to stay away.
The Tree of Life congregation is located in the area cited by police, and the incident occurred on the Jewish Sabbath.
Television pictures showed a police SWAT team and ambulances in the area.
There are multiple casualties, the Pittsburgh Post-Gazette quoted Police Commander Jason Lando as saying.
US President Donald Trump tweeted that people in Squirrel Hill area should remain sheltered. Looks like multiple fatalities.
He added: Beware of active shooter. God Bless All.
It is the latest shooting incident in the United States, where gunmen regularly cause mass casualties and firearms are linked to more than 30,000 deaths annually.
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